According to research papers published in the journal Ageing Cell, it may be possible to reverse individuals biological age with a combination of drugs and growth hormones. Mr. Steve Horvath, who is a geneticist at the University of California, was able to change persons epigenetic or biological age. Approximately for an average of two-and-a-half years after treated with a mixture of growth hormone and two popular remedies used for diabetes medications. The study also reported in the nature Journal that the immune system of the patients has rejuvenated. Biological age is estimated by tracing chemical changes to an organism’s DNA. To assess individuals age, chemical changes or tags are added to DNA. So by looking at such tags a biological age of a person can be estimated.
Two anti-diabetic drugs, namely Dehydroepiandrosterone (DHEA) and Metformin were covered owing to growth hormone rhGH were likely to encourage the onset of diabetes. The impact of the combination of drugs on aging was tested later. These results are introductory owing to the small scale of the clinical trial, and the researchers are recommending attention until extensive studies. Mr. Wolfgang, a cell biologist, told that this study is small and makes it challenging to conclude.
Mr. Horvath has developed some of the most accurate data. The epigenetic clocks have been used to regulate the effectiveness of the medicine cocktail when it comes to biological aging. It was a minor study conducted 2015–2017 on nine men whose age is between 51 and 65 years. This study is known as the Thymus Regeneration, Immunorestoration, and Insulin Mitigation (TRIIM) trial. It is the first individual clinical trial intended to reverse aspects of individual aging. The main purpose of the study was to examine the effectiveness and security of utilizing growth hormone recombinant human growth hormone to rebuild or repair tissue in the thymus gland which is a significant feature of an effective immune system.